The highly sulphated KSPGs of cornea inhibit macrophage adhesion; however, lumican desulphation occurs in corneal disease and localises macrophages to inflamed tissue.108 KSPGs also act as a barrier to neurite outgrowth in vitro and direct axon growth during development and regeneration in vivo.109 KS chains bind to insulin-like growth factor binding protein-2 (IGFBP2)110 and interact with sonic hedgehog (SHH), FGF1, and FGF2.111 KS disaccharides activate Robo-slit to induce Rho GTPase activity. The gene discussed is IGFBP2; the disease is corneal disorder.