FGFR3 and achondroplasia: Surprisingly, Fgfr3 activation in mouse models of ACH (Fgfr3G369C/+, Fgfr3G380R/G380R, Fgfr3Y367C/+) also decreases bone formation and femoral bone mass and alters bone microarchitecture in growing and young adult mice (Lee et al., 2017; Mugniery et al., 2012; Su et al., 2010).