HNF1B and renal cysts and diabetes syndrome: Constitutive inactivation of Hnf1b in the mouse epiblast (Haumaitre et al., 2005; Lokmane et al., 2008, 2010) or specific inactivation of Hnf1b either in renal tubules, liver or pancreas (Coffinier et al., 2002; De Vas et al., 2015; Desgrange et al., 2017; Gresh et al., 2004; Heliot et al., 2013) results in early embryonic or perinatal death, along with far more severe phenotypes than those observed in the context of the RCAD disease.