However, it is more likely that Hnf1b mutant spliced transcripts not degraded by NMD are not translated through a process known as nonsense-mediated translational repression (NMTR), a well-documented mechanism described in several frameshift mutations in cancer cells (You et al., 2007) as well as human dominant diseases associated with PTCs (Barefield et al., 2015; Rio Frio et al., 2008). This evidence concerns the gene HNF1B and cancer.