Additionally, Hnf1b deletion in medullar tubules at relatively later stages resulted in cystic kidneys after birth and downregulation of several cystic disease genes, including the HNF1B direct targets Pkhd1, Pkd2, Kif12 and Umod (Gresh et al., 2004; Hiesberger et al., 2005). Here, HNF1B is linked to Renal cyst.