Moreover, HDAC3 deletion induces cardiac hypertrophy, and global deletion of HDAC3 results in embryonic lethality at E9.5 in the heart [52], whereas its inhibition prevents type 1 diabetic cardiomyopathy via epigenetic regulation of the DUSP5–ERK1/2 pathway [54]. Here, HDAC3 is linked to cardiac hypertrophy.