si-Nrf2 eliminated the protective effect of HDAC3 inhibition on T2DM, as determined by the expression of antioxidant genes (Fig. 7i), increased apoptosis (Fig. 8j and h), increased oxidative stress (Fig. 8k and n), and aberrant tube formation (Fig. 8l and o) and vascular sprouting (Fig. 8m and p). This evidence concerns the gene HDAC3 and type 2 diabetes mellitus.