PECAM1 and type 2 diabetes mellitus: The results of thoracic aortic sprouting, CD31 immunofluorescence staining (Fig. 8a and e), TUNEL assay (Fig. 8b and f), Ki67 detection (Fig. 8c and g), and 3-NT staining (Fig. 8d and h) indicated that Nrf2 knockout abrogated the RGFP966-induced protective effect on T2DM-induced aortic endothelial injury.