SOX9 and pituitary tumor: Based on our data, the ROC curve of SOX9 expression in GH-producing pituitary tumor and normal pituitary tissues revealed the AUC level of 0.755 (95% CI, 0.599–0.911, P = 0.007) with the best cut off value of 0.54 which has 84.5 and 60% sensitivity and specificity, respectively based on the Youden Index (Fig. 2).