Given the potential role of SOX9 in tissue regeneration as well as its relevance to the intracellular pathways regulating tumor cell growth, this study is aimed to evaluate the status of SOX9 in tumor tissues of GH- secreting pituitary adenomas at both gene and protein level to provide pieces of evidence regarding the relevance of this effector with pituitary tumors. Here, SOX9 is linked to neoplasm.