Based on data, the SOX9 gene expression in GH-secreting pituitary tumors was significantly correlated with the SOX9 protein level (P = 0.007), also, in the subgroup of macroadenoma, the SOX9 gene expression was significantly correlated with its protein expression level (P = 0.022) while no correlation was observed regarding the SOX9 gene and protein level in microadenoma group. Here, SOX9 is linked to pituitary tumor.