Levels of GRHL2 were increased in liver tissues of patients with alcoholic liver disease and correlated with decreases in levels of MIR122. Increased levels of MIR122 in hepatocytes of mice with ethanol-induced liver disease and advanced fibrosis reduced levels of HIF1α and reduced serum levels of alanine aminotransferase (ALT). Here, HIF1A is linked to alcoholic liver diseases.