Moreover, previous studies showed that the MHC genes share a common influence on HBV infection, liver cirrhosis, hepatocellular carcinoma [6, 12, 15, 16] as well as associate with different risk in these outcomes [18]; i.e. HLA-DQ, STAT4, C2, HLA-DRB1 for liver cirrhosis and HCC [12], HLA-DQ for CHB [6]. Here, STAT4 is linked to cirrhosis of liver.