Our previous studies [40, 41] showed that NTCP S267F mutation significantly affected the disease progression to cirrhosis (P = 0.017), and hepatocellular carcinoma (P = 0.023) versus CHB [40] and the rs3077:T allele was associated with decreased risk of chronic HBV infection (OR = 0.62, P = 0.001) [41]. The gene discussed is SLC10A1; the disease is Cirrhosis.