In this study, we found that silencing of FTX remarkably inhibited cell activity and Edu positive cell number of PANC-1 and SW1990 cells, and increased the apoptosis rates and the expression levels of c-caspase-3 and c-caspase-12, confirming that silencing of FTX observably inhibited the proliferation activity of PC cells and promoted the apoptosis of cells. Here, CASP12 is linked to pachyonychia congenita.