ADGRG6 and adolescent idiopathic scoliosis: In another study, over‐expression of the Adgrg6 NTF (S1 isoform) was reported to delay ossification of human mesenchymal stem cells in vitro; the authors propose that differential expression of ADGRG6 or its isoforms could contribute to the abnormal curvature of the spine in patients with Adolescent Idiopathic Scoliosis (Xu et al., 2019) (see also Section 3.4).