ADGRG6 and scoliosis: In contrast to the deletion of Adgrg6 in osteoblasts, deletion of Adgrg6 in chondrocyte lineages of the spine in mice resulted in abnormalities of the intervertebral disc (IVD), including mechanical stiffening and eventual disc herniation, or scoliosis, depending on the transgenic driver used (Karner et al., 2015; Liu et al., 2019).