Probands from three consanguineous families with Lethal Congenital Contracture Syndrome 9 (LCCS9), a rare form of Severe Arthrogryposis Multiplex Congenita (AMC), were found to harbor different homozygous recessive mutations in the ADGRG6 coding sequence (Ravenscroft et al., 2015). The gene discussed is ADGRG6; the disease is lethal congenital contracture syndrome 9.