Compared to younger COVID-19 patients under 60 years old, platelets, DBil, IBil, LDH, BNP, CRP, PCT, and IL-10 were all significantly increased in elderly patients (median platelet level, 280 vs. 136×109/L; median DBil level, 3.3 vs. 12.9 μmol/L; median IBil level, 4.8 vs. 12.1 μmol/L; median LDH level, 264 vs. 415 U/L; median BNP level, 185 vs. 918 pg/mL; median CRP level, 14.6 vs. 90.5 mg/L; median PCT level, 0.091 vs. 0.234 ng/mL; and median IL-10 level, 5.36 vs. 43.60 pg/mL) (P-value < 0.05). This evidence concerns the gene NPPB and COVID-19.