RASAL1 and Ureteral obstruction: In experimental models of renal fibrosis involving unilateral ureteral obstruction and folic acid nephropathy, Tampe et al. demonstrated that the anti-fibrotic effects of low-dose hydralazine occurred through demethylation of the RASAL1 promoter, mediated by induction of Tet3 hydroxymethylation [21, 23].