We found this bias especially in SigMod (S5 Fig), which selected three highly central, unassociated genes in both the PPIN and in many of the random rewirings: COPS5, CUL3, and FN1. However, as we showed in Section 3.3 and will show in 3.8, there is evidence in the literature of the contribution of the first two to breast cancer susceptibility. This evidence concerns the gene CUL3 and breast carcinoma.