In agreement with these results, it has been demonstrated that in mouse high levels of PLIN2 are associated with several metabolic diseases, such as obesity, diabetes, fatty liver diseases, atherosclerosis and cardiovascular diseases, while the inhibition of PLIN2 prevents or alleviates these pathologies [1, 7–10]. The gene discussed is PLIN2; the disease is obesity due to melanocortin 4 receptor deficiency.