XRCC5 rs16855458 and rs9288516 have potential biological functions as they cause changes in the binding sites of transcription factors, and correlate with risk for hepatocellular carcinoma,9, 10 whereas XRCC6 rs2267437 and XRCC5 rs3835 were correlated with breast cancer risk in European women.11 This evidence concerns the gene XRCC5 and hepatocellular carcinoma.