However, the role of IL‐22 in the pathophysiology of arthritis remains debated, with RA patients showing increased IL‐22 levels in the plasma and the synovial fluid and anti‐IL‐22 antibodies injections in animals being either protective or detrimental, depending on the injection time, before or after the onset of the disease.34 The gene discussed is IL22; the disease is rheumatoid arthritis.