The adhesion of cancer cells to endothelial cells is therefore a key step in the metastatic process and is believed to be initiated by E- and P-selectin expressed on activated endothelial cells interesting with the tetrasaccharide carbohydrates attached to O-glycans on the surface of cancer cells [11].The adhesion between Acute Myeloid Leukemiacells and endothelial cells requires functional P-selectin and E-selectin [12].This initial contact between ECs and cancer cells is further enhanced by integrins on cancer cells, interacting with intercellular adhesion molecule 1 on ECs [13,14]. This evidence concerns the gene SELE and cancer.