On the contrary, NPSR is widely expressedin several brain regions (i.e., hypothalamus, endopiriform nucleus,amygdala, subiculum, cortex, and nuclei of the thalamic midline).4,5In vivo, NPS has been shown to control severalbiological functions in rodents including stress, anxiety, socialbehavior, locomotor activity, wakefulness, food intake and gastrointestinalfunctions, memory processes, pain, and drug abuse.6,7 Asfar as the therapeutic potential of selective NPSR ligands is concerned,NPSR agonists may be useful as innovative anxiolytics devoid of sedativeeffects, analgesics, and nootropics. This evidence concerns the gene NPSR1 and Anxiety.