NEDD8 and esophageal squamous cell carcinoma: Gene ontology (GO) analysis indicated that several biological processes associated with cell survival—including negative regulation of cell cycle process, regulation of cell cycle arrest, extrinsic apoptotic signaling pathway via death domain receptors, cellular response to DNA damage stimulus, and DNA damage checkpoint—were significantly elevated in NEDD8-knockdown ESCC cells (Figure 3A and 3B).