NEDD8 and carcinoma of esophagus: As shown in Figure 1A, the mRNA expression of NEDD8 was significantly elevated in esophageal carcinoma and correlated with nodal metastasis (normal vs. N0, P = 2.5627E-04; normal vs. N1, P = 8.0956E-07; normal vs. N2, P = 5.5654E-08; normal vs. N3, P = 1.5798E-03; N0 vs. N1, P = 9.8279E-04; N0 vs. N2, P = 9.1616E-04; N0 vs. N3, P = 5.7208E-01).