A total of 20 common risk factors (i.e., age, gender, smoking, and/or alcohol use, weight loss, vomiting, nausea, fatigue, appetite loss, jaundice, abdominal pain, diabetes, depression, AST, ALT, albumin, alkaline phosphatase, GGT, glucose, bilirubin, CEA, and CA 19-9) associated with PC were used with PubMed knowledge to weigh the risk factors. The gene discussed is GPT; the disease is pachyonychia congenita.