EZH2 and cardiac hypertrophy: We previously identified a heart-enriched lncRNA cardiac hypertrophy associated epigenetic regulator (Chaer), which transiently interacts with EZH2 at early phase of cardiac hypertrophy induced by transaortic constriction (TAC) surgery and prevents its targeting to the promoter region of hypertrophic genes (28), implicating a highly dynamic regulation of EZH2 by lncRNAs.