In contrast to the 2006 APS classification criteria and older SLE criteria sets, the 2012 Systemic Lupus International Collaborating Clinics (SLICC) and the 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria include the IgA isotype for aCL and anti-β2GPI (2, 17). The gene discussed is ACLY; the disease is systemic lupus erythematosus.