The validated APS classification criteria from 2006 include immunoglobulin (Ig)G/IgM anti-cardiolipin antibodies (aCL), IgG/IgM anti-β2-glycoprotein-I antibodies (anti-β2GPI), and the lupus anticoagulant (LA) test (4). This evidence concerns the gene CD40LG and systemic lupus erythematosus.