Globulin levels may increase with the accumulation of acute phase proteins, including C-reactive protein and serum amyloid A. Some studies have found that the common variants of TNF receptor superfamily member 13B and other genes are strongly correlated with the increase in immunoglobulin, which suggests that globulin may be related to apoptosis and cancer progression (17). This evidence concerns the gene TNFRSF13B and cancer.