Furthermore, DKK1 plasma levels directly correlated with disease activity parameters in ERA patients at disease diagnosis [DAS44: R = 0.224, p = 0.01 and Clinical Disease Activity Index (CDAI): R = 0.185, p = 0.04, respectively], whereas no correlations were found for OPG or RANKL plasma levels (Figure 2D). The gene discussed is DKK1; the disease is enthesitis-related juvenile idiopathic arthritis.