Finally, at logistic regression model, baseline DAS44 [OR: 2.46 (1.11–5.44)] and osteopenic/osteoporosis status [OR: 7.13 (1.27–39.94)] arose as independent factors of erosiveness, whereas baseline IL-6 plasma levels were not independently associated with bone erosions presence in ERA. This evidence concerns the gene IL6 and osteoporosis.