In particular, as shown in Figures 1A,B, erosive ERA patients had more likely a higher disease activity and inflammatory status as underlined by a significantly higher IL-6 plasma levels (24.53 ± 32.01 pg/ml) and DAS44 (3.82 ± 1.15) than non-erosive ERA patients (IL-6: 19.52 ± 42.99 pg/ml, p = 0.03 and DAS44: 3.43 ± 0.92, p = 0.02, respectively), regardless of ACPA positivity. This evidence concerns the gene PRTN3 and enthesitis-related juvenile idiopathic arthritis.