Different factors could account for this finding, including the IgA-associated protective effects on the gut mucosa (9–11) and the pentameric structure of the IgM that allows their binding to different antigens located on the germ surface or to pathogen-associated molecular patterns (PAMP) with the subsequent activation of the complement (12, 13); moreover, IgM molecules exert an immumodulatory effect by scavenging excessive complement factors and blunting the production of some sepsis mediators (14, 15). Here, CD40LG is linked to Sepsis.