This finding contrasts what has been demonstrated in septic shock patients studied along a 4-week period by Giamarellos-Bourboulis et al. (7) who observed that (a) in S, the levels of native IgM sharply increased for the first 4 days but returned at baseline values after 6 days and remained stable till the 28th day; (b) conversely in NS, the IgM presented only minor fluctuations during the 4 weeks following the onset of sepsis; and (c) at the 28th day, the IgM levels of both groups overlapped. This evidence concerns the gene CD40LG and septic shock.