CD40LG and septic shock: Actually, to overcome the relented or failed increase of the involved Ig as well as the time-dependent effect on the outcome (19) in septic shock patients, recently, Nierhaus et al. (34) suggested a different approach, basically consisting in the administration in the first 6 h of dosages higher than usual possibly followed by an infusion that could be titrated on the blood levels of the IgA and IgM.