Interestingly, this patient did not have epilepsy at the moment of assessment, although it could not be excluded that this might occur in a later stage of life, as was observed in one patient described in Dyment et al. (2019) Although both studies did not further investigate the molecular mechanisms surrounding the disease phenotype, two other research teams performed thorough biophysical characterizations of the two reported TRPM3 disease mutations in in vitro cell systems (Van Hoeymissen et al., 2020; Zhao et al., 2020). Here, TRPM3 is linked to epilepsy.