Subsequently, we further co-cultured Lovo cells or HCT-116 cells with NK cells in different ratios, and we found that after knocking down the expression of KDM4B in CRC cells, the resistance of CRC cells to NK cell-mediated cell lysis caused by IFN-γ treatment was significantly impaired (Figure 2F). Here, KDM4B is linked to colorectal carcinoma.