By co-culturing Lovo cells or HCT-116 cells with NK cells at different ratios, we found that overexpression of KDM4B or HOXC4 in CRC cells significantly mitigated the susceptibility of CRC cells to NK cell-mediated cell lysis caused by Evs treatment (Figure 7E). This evidence concerns the gene HOXC4 and colorectal carcinoma.