Further rescue experiments indicated that upregulation of KDM4B or HOXC4 antagonizes the role of Evs on immune evasion, implying that the involvement of the KDM4B/HOXC4/PD-L1 axis in exosomal miR-15a-mediated immune evasion in CRC. The gene discussed is KDM4B; the disease is colorectal carcinoma.