To comprehensively figure out the effect of KDM4B on the biological functions of CRC cells, we detected the H3K27me3 and HOXC4 protein expression in HCT-116 and LoVo cells after IFN-γ treatment by western blot and found that H3K27me3 was decreased significantly, while HOXC4 was promoted remarkably after IFN-γ (Figure 2A). Here, HOXC4 is linked to colorectal carcinoma.