LGR5 and neoplasm: Jang et al. (2018) found that LGR5 overexpression attenuates proliferation, migration, and colony formation in CRC cells. Besides, LGR5 functions as a tumor suppressor in the late stages of CRC progression and is an independent prognostic marker for better clinical outcomes in CRCs. In the present study, LRG5 (HR = 0.855, P = 0.003) also acted as an independent protective factor for the prognosis of patients with CRC.