Lin et al. (2019) reported that inhibition of PLAU can suppress CRC cell proliferation and progression. In the present study, PLAU (HR = 1.357, P = 0.001) also acted as an independent risk factor for the prognosis of patients with CRC and was negatively correlated with the abundance of infiltrating regulatory T cells in tumor tissue (r = −0.26, P < 0.0001). Moreover, PLAU was positively correlated with the expression of many immune checkpoint genes, including CD274 and CALT4, and may act as a key molecule for tumor cells to escape immune surveillance. This evidence concerns the gene CD274 and neoplasm.