Increased expressions of inhibitory checkpoint proteins [including programmed cell death 1 (PD1), PD1 ligand 1 (PDL1), PDL2, and cytotoxic T lymphocyte protein 4 (CTLA4)] are common features of CRC that protect tumors from destruction by T cells (Juneja et al., 2017). This evidence concerns the gene CD274 and colorectal carcinoma.