Only a few studies have reported methods for effective distinction between bacterial infections and lupus flares in SLE in the past, and they have only explored the indicators, including WBC, CRP, PCT, and nCD64, independently (Hussein et al., 2010; Yang et al., 2010; Serio et al., 2014; Ajmani et al., 2019). This evidence concerns the gene CRP and systemic lupus erythematosus.