Our results showed that genetically engineered bacteria of M-GLP-1 significantly reduced blood glucose and bodyweights of the obese mice induced by HFD, demonstrating the mechanism of anti-obesity of M-GLP-1 strain may be related to promoting fatty acid oxidation and increasing intestinal microbial diversity of the obese mice. The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.