Next generation sequencing (708 cancer genes) of a soft tissue metastasis revealed a homozygous deletion of <i>CDKN2A</i> in addition to the previously known <i>NRAS</i> mutation, as well as amplification of <i>CCNE1</i> and <i>CDK6.</i> Immunohistochemical staining of the altered cell cycle genes confirmed loss of p16, reduced expression of p21 and high expression of CDK6 and cyclin D1. Here, CDKN2A is linked to cancer.