TFEB and neoplasm: The IHC assays revealed that the expression of TFEB was decreased in 22RV1-shTFEB xenograft tumor samples and was increased in the DU145-TFEB xenograft tumor samples compared to the control group Furthermore, ABCA2 expression in the cytoplasm was increased in TFEB-overexpressing xenograft tumor samples and was decreased in TFEB knockdown xenograft tumors (Figure 5E).