Furthermore, to determine whether TFEB might regulate ABCA2 activity during lysosomal biogenesis, which may ultimately influence PCa cell invasion and migration, we silenced ABCA2 expression in DU145-TFEB and DU145-vector cell lines to explore its influence in PCa invasion, migration, and lysosomal biogenesis. This evidence concerns the gene ABCA2 and posterior cortical atrophy.