Previous cancer-related studies have demonstrated that TFEB is dysregulated in many cancers, Sounak et al. have suggested that TFEB is overexpressed in TFEB-rearranged renal cell carcinomas (RCC) and is associated with aggressive biological behavior: TFEB amplification in RCC patients has been associated with poor outcome compared to other types of RCC (34). Here, TFEB is linked to hereditary clear cell renal cell carcinoma.