HIF-1α is degraded under normoxic condition via the proteasome pathway but is stabilized under hypoxia (38).To date, a series of studies have reported that HIF-1α expression could be an important predictor of tumor prognosis, including for hepatocellular carcinoma, cervical carcinoma and lung cancer (39–41). The gene discussed is HIF1A; the disease is hepatocellular carcinoma.