HIF1A and cancer: As both HIF-1α and DPT have been reported to beassociated with cancer cell cycle progression (43, 50), cancer cell microtubule destabilization (45, 51), cancer cell necroptosis (37, 52) and autophagy (23, 53), our data suggest that the effect of DPT on cancer cells might occur through the degradation of HIF-1α.