Similarly, to B16F10 mouse melanoma tumors, mEHT induced DNA damage and p53 activation but in contrary to B16F10, where this led to cell cycle arrest and senescence marked by high p21waf1 expression without pronounced cell death (2) in the A2058 human melanoma xenografts the mEHT-induced p53 expression resulted in strong caspase-3 activation and subsequent apoptosis without significant p21 induction. Here, CASP3 is linked to melanoma.