(3, 32) who demonstrated that in C26 colorectal carcinoma the in vitro mEHT treatment induced p53 activation and caspase dependent cell death similarly to the in vivo experiments, where besides the caspase dependent cell death, they also detected the caspase independent pathway, marked by the elevated expression of apoptosis inducing factor (AIF) (28). Here, AIFM1 is linked to colorectal carcinoma.