Furthermore, alterations in the associated genes (CDK-1, CDK-4, CCNE1, CDKN2A, RBI, NCAPG, AURKA, and CCND2) were determined in five CRC studies (CRC, TCGA, Firehose, CRC, TCGA, Nature, CRC, Pan-Cancer, MSKCC and CPTAC-2). This evidence concerns the gene CCNE1 and cancer.