Voltage-gated potassium channel (VGKC) encephalitis: common classic features of limbic encephalitis early and prominent development of medically intractable epilepsy. circulating VGKC autoantibodies genetic predisposition to VGKC autoimmunity temporal lobe epilepsy T2-FLAIR hyperintense lesions in 1 or both medial temporal lobes and chronic findings of mesial temporal sclerosis on follow-up imaging antibodies to leucine-rich glioma-inactivated 1, contactin-associated protein-like 2, and dipeptidyl-peptidase-like protein-6. The gene discussed is CNTNAP2; the disease is encephalitis.