Our findings suggest that LINC01137, LINC01215, MAPKAPK5-AS1, TPT1-AS1, CARMN, CCDC18-AS1, EPB41L4A-AS, and LINC01214 may be potential diagnostic biomarkers for psoriasis and LINC01137, LINC01215, and LINC01214 may serve as predictive biomarkers for biologics response in psoriasis. Here, TPT1 is linked to psoriasis.