Conditional loss of EZH2 in the uterus upregulated genes associated with uterine diseases, including keratin 5 (Krt5), keratin 15 (Krt15), the maternally-imprinted gene- H19, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), and cell division cycle associated 5 (Cdca5). Here, KRT5 is linked to uterine disorder.