P4HB and cancer: In addition, elevated levels of P4HB in cells and EVs were observed not only in YES2, but also in various types of cachexia‐inducible cancer cell lines originated from both human and mouse, including AGS, BxPC3, and LLC (Fukawa et al., 2016; He et al., 2014; Yang et al., 2019; Zhang et al., 2017).