RBM20 and familial dilated cardiomyopathy: RBM20 mutations affect ~3% of DCM patients and lead to a particularly malignant form of the disease characterized also by conduction system disorders and/or life-threatening arrhythmias (in ~30 and ~45% of patients, respectively; Refaat et al., 2012; Haas et al., 2015; Kayvanpour et al., 2017; van den Hoogenhof et al., 2018).