Also examined was the presence of the mutations (p.Arg3500Gln, p.Arg3500Trp, p.Arg3531Cys, and p.His3543Tyr) in the gene coding for APOB. The FH-causing variants were identified in seven (46.6%) individuals of the 15 screened patients, whereas no mutation was detected in eight patients clinically diagnosed with FH and premature CAD. This evidence concerns the gene APOB and coronary artery disorder.