Accumulating evidence has shown that, in addition to mutations in the LDLR and PCSK9 genes, mutations in other single or multiple genes can contribute to the creation of the FH phenotype (Smilde et al., 2001; Nordestgaard et al., 2013; Cuchel et al., 2014b; Fouchier et al., 2014; Brautbar et al., 2015; Berberich and Hegele, 2019). Here, LDLR is linked to familial hyperaldosteronism.