Nevertheless, whole-exome sequencing has revealed that mutations in the lysosomal acid lipase A (LIPA), ATP-binding cassette sub-family G member 5 and 8 (ABCG5/8), and cholesterol 7 alpha-hydroxylase (CYP7A1) genes phenotypically cause hypercholesterolemia similar to FH in the recessive status (Brautbar et al., 2015; Berberich and Hegele, 2019). Here, CYP7A1 is linked to familial hypercholesterolemia.