SHC1 and cancer: Ueno et al. (2008) found that ERBB3 and ERBB1 dimerized in melanoma cells and promoted the metastasis of melanoma to a certain extent. ERBB3 is overexpressed and activated in a variety of cancers. The regulation of ERBB3 expression and signaling involves many HER3 interacting proteins, including PI3K, Shc, and E3 ubiquitin ligases NEDD4 and Nrdp1 (Mujoo et al., 2014).