In melanoma, KIT, ALK, NTRK1, FGFR4, and MET may not be regulated by the ERBB family, while the genes regulated by the ERBB family are mainly concentrated in the RAS-RAF-MEK-ERK signaling pathway (Wee and Wang, 2017), which is one of the core pathways in the pathogenesis of melanoma (McCubrey et al., 2007) and also a pharmacological target for cancer treatment. The gene discussed is RAF1; the disease is melanoma.