Ueno et al. (2008) found that ERBB3 and ERBB1 dimerized in melanoma cells and promoted the metastasis of melanoma to a certain extent. ERBB3 is overexpressed and activated in a variety of cancers. The regulation of ERBB3 expression and signaling involves many HER3 interacting proteins, including PI3K, Shc, and E3 ubiquitin ligases NEDD4 and Nrdp1 (Mujoo et al., 2014). This evidence concerns the gene EGFR and melanoma.