Among these DEGs, 16 miRNAs and 287 mRNAs had statistically significant impacts on the prognosis of BLCA, among which the top four miRNAs were hsa-let-7c, hsa-mir-99a, hsa-mir-125b-2, and hsa-mir-200c, and the top four genes were HTRA1, ANXA1, EMP1, and FLNC. These DEGs may be potential prognostic biomarkers and therapeutic targets for BLCA. The gene discussed is FLNC; the disease is bladder transitional cell carcinoma.