Among these DEGs, 16 miRNAs and 287 mRNAs had statistically significant impacts on the prognosis of BLCA, among which the top four miRNAs were hsa-let-7c, hsa-mir-99a, hsa-mir-125b-2, and hsa-mir-200c, and the top four genes were HTRA1, ANXA1, EMP1, and FLNC. These DEGs may be potential prognostic biomarkers and therapeutic targets for BLCA. Here, EMP1 is linked to bladder transitional cell carcinoma.