A recent report from Francis et al. (6) elegantly showed in tumor models that intratumoral administration of CTLA-4 and/or PD-1 blocking antibodies ensured optimal access to TDLN (in contrast to systemic administration) and, moreover, that ipsilateral administration on a site different from the tumor but with lymph drainage to the same lymph node stations afforded equal tumor protection. Here, CTLA4 is linked to neoplasm.