The importance of T-cell trafficking from TDLN to tumor was further underscored by findings from Salmon et al. (8), showing that the absence of cDCs, presenting antigen in TDLN, resulted in a failure of CD8+ T cells to enter the tumor parenchyma after anti-PD-1 treatment, suggesting that increased T-cell infiltration was due to trafficking of T cells previously activated in TDLN. This evidence concerns the gene CD8A and neoplasm.