The co-culture of PBMCs with BM-MSCs, both from RA patients or healthy controls, resulted in decrease the production of TNF-α, IL-17, IL-6, IL-2, IFN-γ, and IL-9 by all T-lymphocyte subsets (naive, effector, and memory T-lymphocytes). This evidence concerns the gene IL6 and rheumatoid arthritis.