The dysregulated expression of PD-L1 and PD-L2 caused by a genetic truncation of 3′-UTR has also been identified in EBV+ DLBCL, but not in EBV- DLBCL, which provides another explanation of why highly immunogenic EBV+ DLBCL can escape immune surveillance in young adults (34). This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.