Additionally, the in vivo immunogenicity study revealed that W4P-RBD immunizations induced remarkably higher levels of SARS-CoV-2 RBD- or S1-specific IgG or IgA antibodies in the serum of vaccinated mice that not only efficiently neutralized pseudotyped and wild-type viruses but also exerted strong antiviral effects by blocking cell entry in an infection model of live virus (Figures 2, 3). This evidence concerns the gene PSMD1 and infection.