Marked IgG and IgM AAb responses against lupus-associated autoantigens including ribonucleoprotein, Smith antigen, DNA, histones, Ro/SSA, SSB, and complement by 1 week PI in BALF and 5 week PI in plasma, peaking at 9 and 13 weeks PI, respectively. The gene discussed is SSB; the disease is systemic lupus erythematosus.