STAT1 and infection: When compared to IFNγR1 defects and STAT1 deficiency, IL-12Rβ1 defect had a milder course of the disease which was observed by lower mortality (16% in IL-12Rβ1 compared to 20% in IFNγR1, and 50% in STAT1 defects altogether), fewer patients suffering from infections with multiple organisms, fewer courses of ATT required during the course of disease (32, 33).