When compared to IFNγR1 defects and STAT1 deficiency, IL-12Rβ1 defect had a milder course of the disease which was observed by lower mortality (16% in IL-12Rβ1 compared to 20% in IFNγR1, and 50% in STAT1 defects altogether), fewer patients suffering from infections with multiple organisms, fewer courses of ATT required during the course of disease (32, 33). This evidence concerns the gene IFNGR1 and infection.