AFP and neoplasm: In the early days of DC maturity, tumor cells can secrete a-fetoproteina (AFP) to inhibit FAS and mitochondrial metabolism of DC, which is mediated by AFP downregulating the expression of sterol regulatory element-binding protein-1 (SREBP-1) and PPAR-γ coactivator-1α (PGC1-α), the DC metabolism-regulating molecules.