TNFSF10 and neuroblastoma: But in neuroblastoma (NB), TLR-activated pDCs significantly increase the cytotoxic function of dinutuximab-based NK cells through the TNF-related apoptosis-inducing ligand (TRAIL) death-receptor pathway, increase the expression levels of CD69 and TRAIL, and reduce the risk of recurrence in high-risk patients with NB (129).