The median baseline concentrations of 25 markers were significantly higher in TB patients than ORD patients namely; C3b/iC3b, IL-4Ra, C1q, procalcitonin, CFB, CCL18, GDF-15, VCAM-1, TNF-α, ferritin, MPO, SAA, CRP, IL-2Ra, IFN-γ, IP-10, PDGF-BB, VEGF, pentraxin3, MMP-1, RANTES, TNFRII, MIG, sCD40L, and I-309 (Supplementary Table 3). Here, C3 is linked to tuberculosis.