When further univariate analysis was carried out in study participants from both cohorts excluding those with EPTB, the concentrations of C1q, CC3, C3b/iC3b, MIG, IL-12p70, TNFRII, VEGFR3, I-309, MIP-1a, IP-10, and G-CSF showed significant differences between the pulmonary TB and ORD groups (Supplementary Table 5). This evidence concerns the gene C3 and pulmonary tuberculosis.