These findings of a role for endogenous PPAR-δ in neuroprotection does correspond with past reports of neuroprotective effects of synthetic PPAR-δ agonists GW0742 and GW501516 in cultured neurons (64, 65) and in murine models of Alzheimer's disease (66, 67), stroke (68–71), Parkinson's disease (72, 73), and Huntington's disease (65). Here, PPARD is linked to early-onset autosomal dominant Alzheimer disease.